Modulatory influence of Green tea polyphenols on lipid peroxidation during L-Arginine induced acute pancreatitis in Wistar rats

Green tea polyphenols have gained enormous attention as an effective natural herb that is used in most parts of the world and is a rich source of polyphenols, which are antioxidant in nature. Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Experimental acute necrotizing pancreatitis was induced by intraperitoneal administration of a high dose of L-arginine in rats. This study was focused to study the effect of green tea polyphenols (GTP) on L-Arg induced AP in rats. GTP was pretreated at a dose of 20 mg/ kg b.wt. for 3 days then AP was induced by intra peritoneal (i.p.) injection of L-Arg (3.2 g/kg b. wt.) twice at 1 hour time interval. Markers such as serum amylase, pancreatic and lung myeloperoxidase (MPO) were significantly increased in AP induced animals, oxidants and antioxidants such as malendialdehyde (MDA) and glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) were significantly decreased in AP induced animals except MDA, these parameters were brought back to near normal status on pretreatment with GTP. The result suggests that GTP pretreatment offered a significant protection against AP and might be a promising potential candidate.